Cerebral Palsy (CP) is a group of disorders that affects the ability of movement, posture and muscle tone among children. Generally, CP occurs among children even before birth and is characterised by damage to the developing brain. The damage occurring in the brain affects a child's ability to control their movement. 

Risk Factor Associated with Cerebral Palsy

Several risk factors lead to CP among children that including: 

• Prenatal Factors: Occurrence of infection such as rubella, exposure to toxic chemicals or incorrect or harsh medication during pregnancy

• Birth Complications: Premature birth of the child or birth complications. Lack of oxygenation in the brain of the child. 

• Postnatal Factors: Injury, infection, or trauma to the brain after the child's birth. This is the least common risk factor, but it generally occurs at an early stage. 

Conventional Cerebral Palsy Treatment

Currently, there are various conventional Cerebral Palsy Treatments available that focus on management aspects. The popular treatments are as follows: 

• Occupational Therapy: Cerebral palsy occupational therapy focuses on helping with day-to-day activities like eating, walking, using the washroom, playing, getting dressed, etc. The therapy focuses on improving the physical and cognitive abilities of the child, along with the development of their fine motor skills. The therapy improves the chances of independence in children and improves their ability to perform daily life activities. Some common examples included in Cerebral palsy occupational therapy are sensory integration therapy, using adaptive tools, and fine motor training.

• Physical Therapy/ Physiotherapy: Physical therapy focuses on improving the physical movement of the child. The primary focus remains on restoration of the physical independence, social and psychological well-being within their known environment, like home, schools, community, etc. Physiotherapy focuses on improving core motor skills, positioning, sitting, walking, etc. 

• Palliative Care: Medications that can relax stiffness or overactivation of the muscle are prescribed to the children. For children with CP experiencing frequent seizures, standard epileptic medications are provided. 

Despite the presence of various conventional cerebral palsy treatments, none of the therapies promises permanent solutions.  Hence, the interest towards regenerative medicine is growing rapidly among healthcare practitioners.  

Stem Cell Therapy for Cerebral Palsy

Stem cell therapy for cerebral palsy in the area of regenerative medicine is gaining increased interest as it focuses on the curative solution. Stem Cell Therapy is often considered the newest treatment for cerebral palsy that aids in the regeneration of the damaged or degenerated nerves, hence curing the problem and restricting the ongoing changes. The common advantages of using  Stem cell therapy for cerebral palsy include: 

• Increased production of neurotrophic factors that aid in the proliferation and differentiation of the nerve cells

• Increased production of new blood vessels, hence promotes adequate supply of blood and oxygenation in the brain

• Increase brain myelination by boosting the production of oligodendrocytes

• Significantly lowers free radical production, which is responsible for excessive damage to the neurons

• Significant reduction of inflammation in the brain and improvement of  neural connections

The standard type of stem cells that have shown a high success rate in cerebral palsy are mesenchymal stem cells (MSCs) obtained from umbilical cord or bone marrow, with the least chances of immune rejection. 

Stem Cells Therapy for Cerebral Palsy: Latest Advances

Researchers believe the significant advancement in the area of stem cell therapy for cerebral palsy is via the use of MSCs and stem cells obtained from umbilical cord blood or the donor or preserved from the own cells. The clinical trials' title dates have shown better success based on various factors such as:

• Age: yonder patient showed better response to stem cell therapy in comparison with older patients

• Complexity: Clinical manifestations based on complex etiologies are classified as spastic CP, ataxic CP, dyskinetic CP, and mixed type. The clinical trials reflected distinct outcomes based on the type of CP.

• Route of administration: Two popular administration routes include intravenous administration and lumbar puncture, while brain surgery and nasal administration were the least common routes of administration. Clinical trials displayed the highest success rate with intrathecal administration (lumbar puncture) with the least side effects that could be managed via medication.

Though the popularity of stem cell therapy for cerebral palsy is growing, there is an intense need for thorough investigation that focuses on minute aspects to gain a definite conclusion. 

Challenges associated with the Newest treatment for cerebral palsy

There are various challenges associated with the success of Stem Cell Therapy for Cerebral Palsy, including:

• Wide range of variability in outcome

• Lack of a standardised protocol globally based on patient type

• Lack of long-term safety evaluation

Stem Cell Therapy for Cerebral Palsy- What to Keep in Mind 

The combinatorial approach, like stem cell therapy with exosomes and medication, can display superior outcomes.

• Parents opting for stem cell therapy for their child must consult renowned clinics and an experienced healthcare practitioner. 

• Stem cells procured must be from a renowned laboratory that strictly maintains the standards for their production. Advancells is a well-acclaimed manufacturer of stem cells that follow stringent regulatory guidelines to assure product quality.

Alzheimer’s disease involves a gradual deterioration of memory, a decline in cognitive abilities, and challenges in performing everyday tasks. Dementia is primarily driven by this leading factor. Upon closer examination, statistics show that 80% of dementia cases are attributed to Alzheimer’s (Source: Alzheimer’s Association). Despite the rapid advancements and growing insights into the human brain, the root causes of diseases remain elusive. Treatment for Alzheimer’s disease is challenging due to the limited understanding of its underlying causes.

Like there are tons of new studies popping up that showcase some super cool meds and next-level therapies, like stem cell treatment, which is giving us some serious hope for handling the disease better. In this blog, we are going to discuss how stem cell therapy for Alzheimer’s is providing hope to the patients.

Traditional Approaches to Alzheimer’s Treatment

So when it comes to the Treatment of Alzheimer’s Disease, we are currently focused on managing and allevating the symptoms. But what is truly the need of the hour is an approach that addresses the core of Alzheimer’s. We know there is one sure reason that contributes to the progression of disease. Researchers have named them amyloid plaques. Because the situation is pretty serious and cases keep going up, researchers have managed to come up with a few drugs. So, like, the drugs that we are talking about are donepezil, rivastigmine, and memantine. The main goal of these meds is to slow down how the symptoms get worse. Just to be real, these meds don’t actually stop the disease from getting worse; they just help to slow it down a bit.

To imagine this, you can think of it as: let’s say normally it takes 1 year for symptoms to worsen, then with this drug the worsening will happen by, say, 1.5 years. This hypothetical example shows how the drugs do reduce the degeneration rate, but it does not stop it. What’s more, these drugs influence the chemical centers that influence memory and cognitive abilities. This provides a modest yet significant form of relief.

So, like, the FDA just gave the green light to some interesting medicines like lecanemab (Leqembi). This drug is unique in its ability to target those pesky amyloid plaques in the brain. Now to be able to target them is a huge deal when it comes to Alzheimer’s disease. They are not our traditional medications, but they are rather like immunotherapies. They help our brain to get rid of the nasty amyloid buildup in the brain. Use of this drug have shown some promise in clinical trials, but they definitely come with risks. We would say these risks are skewed towards the high danger signals. There’s a chance of cerebral edema or hemorrhage, both of which are kind of serious. They can also lead to life threatening conditions.

A New Frontier: Stem Cell Therapy for Alzheimer’s

So, like, even though the meds we have now help with symptoms, there are some fresh ideas being looked at to really tackle the problem more effectively. One cool approach is “Stem Cell Therapy for Alzheimer’s.” This therapy is all about bringing back those damaged brain cells, tackling the real issue behind Alzheimer’s instead of just dealing with the symptoms.

So, like, in India, clinics are totally getting into stem cell treatment for Alzheimer’s. They’re using stem cells more and more to tackle neurological issues. Stem cells can totally turn into different types of cells, like neurons, which are super important for how our brains work. Scientists are looking to transplant these cells into the brain to replace the damaged ones from Alzheimer’s disease, which could totally stop or even turn back the decline in cognitive function.

Why Stem Cell Therapy?

Stem cell therapy, or SCT in short, is being hailed as a revolutionary treatment. It is all because of the ability of the stem cells to repair and regenerate damaged tissue. These cells can be attenuated or primed to find the damaged tissue and then repair it. Several preclinical trials have shown that stem cells can be used to better the conditions of animal models when stem cells are used. If you wish to read this research, we are sharing some studies with you. Neishaboori et al. 2022 DOI: 10.1002/prp2.977, Regmi S et al. 2022 DOI: 10.3389/fnmol.2022.1011225, and Fan et al. 2014 DOI: 10.1002/med.21309. These review articles raise valid questions and give ideas of how stem cells are actually transforming the treatment of Alzheimer’s disease.

There are a bunch of different stem cell sources that people are checking out for treatment options. Researchers are using cells from bone marrow, fat tissue, and umbilical cords. So, like, there’s a chance we could use induced pluripotent stem cells in clinical trials, which is pretty cool. But there are a bunch of rules and ethical vibes we need to think about with these. So, like, the early stage clinical trials are looking pretty promising, right? Stem cells are showing some solid potential for boosting memory, cognitive skills, and just everyday stuff.

Here’s how stem cell therapy for Alzheimer’s offers a promising avenue for future treatment:

• Regeneration of Brain Cells: Stem cells can differentiate into neurons. This can potentially replace the brain cells damaged by Alzheimer’s disease.

• Reduction of Inflammation: Inflammation plays a significant role in the progression of Alzheimer’s. Stem cells can modulate immune responses and reduce inflammation. This enables the brain to prevent further damage.

• Potential to Slow Down Disease Progression: Stem cell therapy has the potential to target the underlying cause, slowing or halting disease progression.

Challenges and Future Outlook

Even though it sounds super promising, stem cell therapy is still just in the experimental phase for Alzheimer’s disease. There are some major roadblocks we need to tackle before this therapy can really become the standard treatment. The researchers and doctors have to go through a long list of regulations and ethical concerns. If they overcome this, the tricky nature of the disease means doctors cannot predict what will happen.

That said, there are several places, like India, where the service providers are able to overcome and comply with all the regulatory and ethical concerns. This is the reason why Stem Cell Treatment for Alzheimer’s in India is turning into a super appealing choice for patients from around the world. Clinics are totally serving up next-level treatments for way less than what you would pay in Western countries, so it’s a solid choice for a lot of people.

Conclusion

Even though we are still trying to find a cure for Alzheimer’s, the progress in the medical realm is giving us hope. This hope comes in the form of drug therapy and innovative treatments like stem cell therapy. With new drugs that tackle those amyloid plaques and combining them with SCT that can regenerate brain cells. We could be moving towards a future where Alzheimer’s isn’t just a permanent struggle anymore.

If you or someone you know is facing Alzheimer’s, hitting up your neurologist ASAP is a solid move. With all the cool research going on

, we could be super close to discovering a treatment for Alzheimer’s disease. That’s pretty lit, right? If you’re curious about whether stem cell therapy for Alzheimer’s could be an option for you, hit us up at +919654321400.

Autism spectrum disorder is a condition that is increasingly seen in newborns and children, between the ages of 2 and 5. It's important to note that ASD, also known as autism, is more of a disorder than a disease. While the exact cause remains unknown, children with autism display patterns. Interestingly, every child exhibits a manifestation of autism symptoms.

Notably, doctors and researchers have discovered that Exosome therapy shows promise as a Treatment for autism. This blog will delve into how exosomes can enhance brain plasticity in children and explore the growing popularity of Exosome Therapy, for treating autism in India and globally.

The Autistic Brain and Neuroplasticity

We have all seen numerous online shows that offer a word of wisdom: Brain is a very wonderful thing and can do anything we put our minds to. This ability of our brain to change and adapt to environmental cues is referred to as neuroplasticity. Human brains have been seen to stay receptive to improvement throughout one's life. It all starts with the brain forming new connections, and strengthening existing ones. This inherent potential for change in our brain is what offers a powerful tool to improve the lives of children who are experiencing ASD.

However we look at it, a normal brain and the brain of an autistic child are both identical. It means there are no structural changes in the brain. Now, if you look at the autism brain under the microscope, you will find that there are very few connections that normally must be present. These connections, scientifically called synapses, manifest in the areas related to social processing, communication, and the sensory abilities of the brain of a child with autism.

But, there is good news for parents and their children!

Researchers have found that autistic brains are remarkably plastic, even though they are neurodivergent. It means that if we intervene early in child development, we will be able to help the children go through a normal development process.

Why is Neuroplasticity such an Important Thing?

Well, to explain neuroplasticity, let's look at an analogy.

Imagine your brain as a city with well built multiple roads, and neuroplasticity can be referred to as a road-making crew. The crew is always ready to work and also gets to work when you start to learn new things. You need a new road to transfer information from one place to another. Neuroplasticity, the new road-making crew, is building new roads (new connections formed), widening the existing roads and improving the type of road formed (strengthened connections), and even entire neighborhoods can be redesigned (reorganization of brain regions). This inherent potential for change offers a powerful tool for understanding and potentially improving the lives of individuals with Autism Spectrum Disorder (ASD).

So, this means that the autistic brain may be particularly receptive to interventions that promote positive change during this critical developmental window.

Exosomes, the Tiny messengers with the Power to Bring Big Changes

Exosomes are nanosized, membrane-bound vesicles that all cells secrete for communication purposes. They are microscopic messengers that carry with them peptides, nucleic acid, lipids, and growth factors that influence the function where the exosomes offload their contents. Now, because the exosomes have been shown to pass through the blood brain barrier, they can go right through it and give all the necessary components and signals to promote the growth and development of new brain cells and connections.

To understand what I just explained, let's revisit our example of our brain with a city of roads. In this city we need a continuous supply of construction materials, and this is what exosomes do. They carry important signals, like growth factors, that help the neurons build stronger roads and faster delivery of the signals.

Harnessing Neuroplasticity for Positive Outcomes

While there is hope, when using Exosome Therapy, it's essential to consider that it's a small part of the solution. It is necessary for parents to enroll their children in speech and occupational therapy, which end up aiding individuals with Autism spectrum disorder to learn new tasks at a faster pace. This fast pace is due to the fact that the brain already has all the required components to build the road.

The idea of neuroplasticity offers a view on supporting those with ASD. By recognizing the brain's ability to change, we can discuss it with the doctors to adopt an approach that blends specific interventions, with methods to enhance the overall well being and growth of our children. This might involve improving habits, sleep patterns, and physical exercise—all elements that can impact neuroplasticity. The habits we must take care of include diet, building a routine, and promoting new activities.

Conclusion

The brain's innate capacity to adapt and establish connections throughout life serves as an asset in supporting their growth. While exosome therapy shows promise in Autism Spectrum Disorder Treatment it's essential to recognize that it is one aspect of the picture. By integrating targeted interventions such as speech and occupational therapy with methods that enhance brain health and growth we can adopt a holistic approach. This may involve optimizing nutrition, sleep habits and physical exercise – all factors that can impact neuroplasticity. Embracing neuroplasticity enables us to change our perspective on ASD, of viewing it as a fixed condition we see it as a range of possibilities. Through research, collaboration and a dedication to unlocking the potential of the brain we can pave the way for a brighter future for children, with ASD, empowering them to achieve their full potential.