How does wegovy work?

  • December 22, 2025 9:44 PM PST

    Wegovy (semaglutide) works by mimicking a natural gut hormone called glucagon-like peptide-1 (GLP-1) to regulate appetite, slow digestion, and help control blood sugar levels. These actions lead to reduced calorie intake and significant weight loss when combined with a healthy diet and increased physical activity.

    Key Mechanisms of Action

    • Appetite Suppression: Wegovy acts on areas of the brain involved in appetite regulation, which increases feelings of fullness and reduces feelings of hunger and food cravings. Many users report that this effect "quiets down food noise" in their heads, making it easier to manage eating habits.
    • Slowed Digestion: The medication slows down gastric emptying, the rate at which food leaves the stomach. This helps you feel fuller for longer after meals, contributing to lower overall food consumption.
    • Blood Sugar Regulation: Wegovy promotes the release of insulin when blood sugar levels are high and decreases the secretion of glucagon, a hormone that raises blood sugar. This helps to keep blood sugar levels more stable, which can reduce cravings and energy crashes.
    • Changes in Food Preference: Some studies suggest that Acquista Wegovy in Italia may also influence preferences, potentially reducing cravings for high-fat or high-sugar foods. 

    How It Is Used
    Wegovy is administered as a once-weekly subcutaneous injection (under the skin) in the abdomen, thigh, or upper arm. 

    • Dosing Schedule: To minimize side effects, treatment begins with a low dose (0.25 mg), which is gradually increased over several weeks until a maintenance dose (usually 2.4 mg) is reached.
    • Lifestyle Changes are Essential: Wegovy is not a standalone treatment. Its effectiveness is maximized when used alongside a reduced-calorie diet and a regular exercise program. Clinical trials have shown that patients using Wegovy with lifestyle changes lost significantly more weight than those relying solely on diet and exercise.
    • Long-Term Use: The medication is generally intended for long-term use, as weight gain may occur if treatment is stopped.